Mysticism: The way brains sniff glue?

Struck me that trance and mystic mental states in general are a kind of high one learns to enjoy from an ordinarily noxious cognitive dissonance--such as between "the everything" and "the one." That can't be healthy. On the other hand, it does seem like what William James had in mind when he called prayer the "sovereign cure for worry" (allegedly, I can't find the reference). Through prayer we can envision circumventing the ineluctable, see how good may come of bad and construe what things mean as what they don't.
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By the way, let me second my occasional phronesisaical colleague helmut's grave recommendation of this article on the political influence of a publicly little known group of extreme-conservative, mystically-minded Christians.